Ingredients / Hyaluronic Acid

Hyaluronic Acid

A glycosaminoglycan humectant. Widely used for hydration. Evidence is strong for surface hydration effects.

Understanding evidence levels
In VitroCell or tissue culture experiments — no human or animal data.
Ex VivoSkin model or tissue experiments — not in living humans.
Animal StudyResults in animals only — may or may not translate to humans.
Small Human StudySmall or uncontrolled human study — preliminary results.
Controlled TrialControlled human study (often randomized) — stronger evidence.
Systematic ReviewSummary and analysis of existing published studies.
Meta-AnalysisStatistical pooling of results from multiple studies.
GuidelineProfessional guidance or consensus statement from a dermatology society.

Research findings(228)

Ex VivoSkin model or tissue experiments. Not in living humans.Skin Barrier DamagePublished: August 5, 2026

Researchers Develop New Skin Delivery System for Resveratrol

A new delivery system for the antioxidant resveratrol was studied for its ability to penetrate deep into the skin. Researchers found that this system, called PEG-liposomes, may help improve skin appearance by promoting collagen remodeling and reducing oxidative stress. The system was tested in combination with micro-needling, a technique that uses small needles to create micro-injuries in the skin.

Why it matters: This study may help improve our understanding of how to deliver antioxidants deep into the skin, which could lead to new treatments for skin aging.

This study was conducted in a lab setting using ex-vivo samples, and its findings have not been tested in human subjects. The study's results may not be directly applicable to real-world skin conditions.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Skin Barrier DamagePublished: July 28, 2026

Researchers studied copper hydrogel for treating seborrheic dermatitis

A copper hydrogel was tested for its potential to treat seborrheic dermatitis, a skin condition associated with a fungal overgrowth. The gel showed promise in lab experiments by killing the fungus and reducing inflammation. In a small animal study, the gel helped to repair skin lesions and improve skin health.

Why it matters: This research may help us better understand how to treat seborrheic dermatitis, a common skin condition that can be challenging to manage.

This study was conducted in guinea pigs and its results may not translate directly to humans. Further research is needed to confirm these findings.

PubMed
Small Human StudySmall or uncontrolled human study. Results are preliminary.WrinklesPublished: July 23, 2026

Low-Cross-Linked Hyaluronic Acid May Help Reduce Facial Wrinkles

Researchers studied a new type of hyaluronic acid to see if it could reduce fine wrinkles around the eyes and mouth. A small group of people received injections every 4 weeks for 3 months, and their skin was evaluated for 6 months. The results showed that the wrinkles became less severe and the skin quality improved.

Why it matters: This study may help us understand how to improve skin quality and reduce wrinkles in delicate facial areas.

This study had a small sample size of 25 participants and was observational, meaning it did not have a control group.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Published: July 22, 2026

Researchers developed a new hydrogel to help heal diabetic wounds

A small study suggests that a new hydrogel may help heal diabetic wounds by reducing bacterial infections and inflammation. The hydrogel releases special particles that kill bacteria and reduce inflammation. It also helps the body's natural healing processes by releasing certain chemicals.

Why it matters: This research may help improve our understanding of how to treat diabetic wounds, which can be challenging to heal.

This study was conducted in a lab and involved animal models, so its results may not directly apply to humans. Further research is needed to confirm its effectiveness in humans.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Published: July 21, 2026

Researchers studied a new hydrogel for wound healing

A new hydrogel was created to help wounds heal faster. It has antibacterial properties and can promote cell growth. The hydrogel was tested in lab experiments and animal studies.

Why it matters: This research may help us understand how to create new treatments for wound infections.

Lab experiments and animal studies only; results may not translate to human skin.

PubMed
Small Human StudySmall or uncontrolled human study. Results are preliminary.WrinklesPublished: July 15, 2026

Microneedle Therapy May Help Improve Enlarged Pores and Fine Wrinkles

A small study in Korea looked at using a microneedle therapy system combined with a topical glucose solution to improve skin texture, pore size, and fine wrinkles. Researchers found that many patients reported improvements in their skin, but more research is needed to confirm these results. The study had a small sample size and did not include a control group.

Why it matters: This study may help skincare professionals understand new treatment options for improving skin appearance.

This study had a small sample size of 40 patients and did not include a control group, which limits its findings. The study also had a short duration of 12-16 weeks, and more research is needed to confirm the long-term effects of this treatment.

PubMed
Small Human StudySmall or uncontrolled human study. Results are preliminary.AcnePublished: July 1, 2026

Researchers Found a Holistic Skin Management Approach May Help Improve Acne Scarring

A small study presents a holistic skin management protocol for acne scarring that combines an injection-based treatment with a daily skincare regimen. The injection procedure involved administering cross-linked hyaluronic acid and microdroplet botulinum toxin. Researchers found that this integrated approach effectively improved skin quality in a patient with acne scars.

Why it matters: This study may contribute to a better understanding of how to manage acne scarring and improve skin texture.

This is a case report, which means it's based on a single patient's experience, and more research is needed to confirm these findings.

PubMed
In VitroCell or tissue culture experiments. No human or animal data.AcnePublished: June 26, 2026

Blue Light May Help Treat Acne with New Skin Formula

Researchers developed a skin formula that releases a helpful gas called nitric oxide when exposed to blue light. This gas may help treat acne by reducing inflammation and killing bacteria. The formula also contains hyaluronic acid, which can help soothe the skin.

Why it matters: This study may help us understand new ways to treat acne, a common skin condition that can be difficult to manage with a single treatment.

This study was conducted in lab experiments only, using skin cells and artificial skin models. The results may not translate to real-world use or human skin.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Published: June 20, 2026

New Hydrogel May Help Treat Bacterial Wounds

Researchers developed a special hydrogel that can be activated by near-infrared light to release medicine and kill bacteria. In lab experiments, this hydrogel was effective against two types of bacteria. It also showed promise in animal studies by reducing inflammation and promoting healing.

Why it matters: This study may help us understand how to develop new treatments for bacterial infections in wounds.

This study was conducted in a lab and on animals, and more research is needed to confirm its effectiveness in humans. The study's results may not translate directly to human skin.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Skin Barrier DamagePublished: June 4, 2026

Citrus Pomace Extract May Help Protect Skin from Damage

Researchers studied a new way to extract beneficial compounds from citrus pomace, a byproduct of citrus juice production. They found that the resulting extract, when tested in lab experiments and on mice, showed potential skin-protective effects. The extract may help reduce inflammation and improve skin barrier function.

Why it matters: This research could lead to the development of new skincare products or ingredients that help protect skin from environmental stressors.

This study was conducted in lab experiments and on mice, and its findings may not directly translate to human skin. Further research is needed to confirm these results.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Published: June 1, 2026

New Hydrogel May Help Treat Infected Diabetic Wounds

Researchers developed a special hydrogel that may help treat infected diabetic wounds by killing bacteria and reducing inflammation. In lab experiments, the hydrogel was able to eliminate nearly all bacteria and promote healing in infected wounds. However, more studies are needed to confirm these findings.

Why it matters: This research may help improve our understanding of how to treat complex skin infections and promote wound healing.

This study was conducted in lab experiments using animal models and may not directly translate to human skin. Further research is needed to confirm these findings and determine the safety and efficacy of this hydrogel in humans.

PubMed
Animal StudyResults in animals only. May or may not translate to humans.Published: May 29, 2026

Sprayable Nanoplatform May Help Diabetic Wounds Heal Faster

Researchers developed a sprayable nanoplatform that combines a hyaluronic acid hydrogel with a near-infrared light-activated system. This system may help clear oxidative stress, promote blood vessel growth, and fight infection in diabetic wounds. In lab experiments and animal studies, the nanoplatform showed promise in accelerating wound healing.

Why it matters: This research may contribute to the development of new treatments for diabetic wounds, which can be challenging to heal.

This study was conducted in lab experiments and animal models, and its findings may not directly apply to human skin. Further research is needed to confirm the effectiveness and safety of this nanoplatform in humans.

PubMed